무기인산염과 탈단백우골의 혼합사용이 골재생에 미치는 효과
Effect of deproteinized bovine bone mineral soaked in inorganic polyphosphate on bone regeneration
나성윤, 허익, 정종혁, 권영혁, 박준봉,
소속 상세정보
나성윤 ( Na Seong-Yoon ) - 소속확인중
허익 ( Herr Yeek ) - 경희대학교 치과대학 치주과학교실
정종혁 ( Chung Jong-Hyuk ) - 소속확인중
권영혁 ( Kwon Young-Hyuk ) - 경희대학교 치과대학 치주과학교실
박준봉 ( Park Joon-Bong ) - 경희대학교 치과대학 치주과학교실
KMID : 0363020070370010077
Abstract
This study was performed to evaluate the effect of deproteinized bovine bone mineral soaked in inorganic polyphosphate on bone regeneration in the calvaria of rabbit in the procedure of guided bone regeneration with titanium reinforced expanded polytetrafluoroethylene(TR-ePTFE) membrane. The rabbits were divided into four groups. Control group used TR-ePTFE membrane filled with de-proteinized bovine bone mineral, experimental group I used TR-ePTFE membrane and deproteinized bovine bone mineral soaked in 4% inorganic polyphosphate, experimental group II and III used TR-ePTFE membrane and deproteinized bovine bone mineral soaked in 8% or 16% inorganic poly-phosphate respectively. After decortication in the calvaria, GBR procedure was performed on 8 rabbits with only TR-ePTFE membrane or titanium reinforced ePTFE membrane filled with deproteinized bovine bone mineral soaked in inorganic polyphosphate. The animals were sacrificed at 4 weeks, and 8 weeks af-ter the surgery. Non-decalcified specimens were processed for histologic analysis, and new bone for-mation was assessed by histomorphometric as well as statical analysis. 1. Both control group and experirrental group dermnstrated increasing of new bone formation until 8weeks. 2. At 8 weeks, experimental group I and group II showed the significant difference compared to control group in new bone formation. Especially experimental group II showed the most in-creasing of new bone formation. 3. The higher concentration of inorganic polyphosphate filled, the more volume of bone formation pro-moted, but experimental group III did not reveal significant difference compared to contol group. 4. Deproteinized bovine bone mineral did not resorbed at all until 8 weeks. These results suggest that inorganic polyphosphate has a promoting effect on bone regeneration. possibly by enhancing osteoconductivity of the carrier and by increasing osteoinductivity of the defected alveolar bone tissue, but not as we respect.
키워드
Inorganic polyphosphate;Bone regeneration;Osteoconductivity;Osteoinductivity
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